氮化物

前一段時(shí)間發(fā)布過利用DPPA通過Mitsunobu反應(yīng)取代羥基合成疊氮化物的文章（點(diǎn)擊：Mitsunobu反應(yīng)合成疊氮化合物），但Mitsunobu反應(yīng)會(huì)生成大量的副產(chǎn)物，不易純化。下面介紹一種可以得到相同產(chǎn)物的方法，利用DPPA和DBU，可以取代羥基得到構(gòu)型翻轉(zhuǎn)的疊氮化物，此反應(yīng)生成副產(chǎn)物磷酸二苯酯和DBU鹽都可以用水洗掉，可以很好的避免消除產(chǎn)物。但此反應(yīng)，只對(duì)于活性醇（芐醇或羧酸α位羥基）效果較好。

反應(yīng)機(jī)理

在DBU堿性條件下醇和DPPA反應(yīng)得到磷酸酯，取代下來的DBU疊氮鹽對(duì)磷酸酯進(jìn)行SN2反應(yīng)，構(gòu)型翻轉(zhuǎn)。

General Procedure:A mixture of the alcohol (10 mmol) and diphenylphosphoryl azide (3.3 g, 12 mmol) were dissolved in dry solvent (18 ml). To the mixture at 0°C, under N2 was added neat l,8-diazabicyclo[5.4.0]undec-7-ene (1.8 ml, 12 mmol). The reaction was warmed to room temperature and stirred until complete. The resulting two phase mixture was washed with H2O (2 x 10 ml) and 5% HC1 (10 ml). The organic phase was concentrated in vacuo and purified by silica gel chromatography using 95:5

(v:v) hexane: ethyl acetate.

(S)-(+)-ethyl lactate(2.54 g, 21.5 mmol) and DPPA (7 g, 25.4 mmol) were reacted with DBU (3.1 ml, 20.7 mmol) in THF (35 ml) at 20°C for 48 h. The batch was diluted with 5:1 hexane:ethyl acetate (120 ml) and washed with H2 O (2 x 40 ml) and 5% HC1 (40 ml). The yield by HPLC assay was 87%. HPLC conditions [CH3CN:H2 0 gradient elution from 50:50 to 70:30 in 15 min,

flow =1.5 ml/min, U.V.detection at 210 nm] tR 4?5 min. The batch was concentrated and distilled to afford 2.2 gm (72%) of the volatile azide.

參考文獻(xiàn)

J. Org. Chem., 1993, 58(22), pp 5886–5888